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Related Experiment Videos

Tolerance to cocaine's rate-increasing effects upon repeated administration

K F Schama1, M N Branch

  • 1University of Florida.

Journal of the Experimental Analysis of Behavior
|July 1, 1994
PubMed
Summary

Cocaine administration increased response rates in squirrel monkeys under fixed-interval schedules. However, chronic cocaine exposure reduced these increases, suggesting tolerance development to its stimulant effects.

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Area of Science:

  • Behavioral pharmacology
  • Primate research
  • Neuroscience

Background:

  • Fixed-interval schedules are used to study reinforcement.
  • Cocaine is a stimulant with known behavioral effects.

Purpose of the Study:

  • To investigate the effects of acute and chronic cocaine administration on response rates in squirrel monkeys.
  • To examine how cocaine affects behavior under fixed-interval schedules.

Main Methods:

  • Four squirrel monkeys were trained on fixed-interval schedules (5-min or 8-min).
  • Cocaine or saline was administered acutely before sessions.
  • A dose showing acute effects was then administered chronically.

Main Results:

  • Acute cocaine increased response rates in most subjects.

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  • One subject showed smaller increases, with effects concentrated early and mid-interval.
  • Chronic administration attenuated the rate-increasing effects of cocaine observed acutely.

    • Conclusions:

    • Cocaine can increase response rates in squirrel monkeys under fixed-interval schedules.
    • Chronic cocaine administration leads to reduced behavioral effects compared to acute administration.
    • These findings suggest the development of tolerance to the stimulant effects of cocaine with repeated exposure.