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Accelerated nodulosis, pleural effusion, and pericardial tamponade during methotrexate therapy
M Abu-Shakra1, P Nicol, M B Urowitz
1University of Toronto Rheumatic Disease Unit, Wellesley Hospital, ON, Canada.
The Journal of Rheumatology
|May 1, 1994
Abstract:
We describe a patient with seropositive erosive rheumatoid arthritis (RA) who developed accelerated nodulosis, pleural effusion, and pericardial tamponade during methotrexate (MTX) therapy while her arthritis remained inactive. MTX is an effective therapy for the articular manifestations of RA. However, on occasion it may result in triggering the development of extraarticular manifestations of RA.