Down syndrome prevalence at birth--United States, 1983-1990

Area of Science:

• Genetics and Birth Defects
• Epidemiology
• Public Health Surveillance

Background:

• Down syndrome (trisomy 21) is a significant birth defect and cause of intellectual disability.
• The prevalence of Down syndrome is known to increase with maternal age.
• Limited national data exists on the birth prevalence and trends of Down syndrome.

Purpose of the Study:

• To determine the birth prevalence of Down syndrome (DS) in the United States.
• To describe trends in DS birth prevalence from 1983 to 1990.
• To provide national population-based estimates of DS.

Main Methods:

• Analysis of data from 17 states with population-based birth defects surveillance programs.
• Inclusion of live-born infant data.
• Examination of birth years between 1983 and 1990.

Main Results:

• The study analyzed birth defects data from 17 states.
• Trends in Down syndrome prevalence were described for the period 1983-1990.
• Population-based estimates of DS were determined.

Conclusions:

• The report summarizes the findings of the CDC's analysis on Down syndrome prevalence and trends.
• The study provides crucial epidemiological data on Down syndrome in the US.
• Understanding DS prevalence is vital for public health planning and resource allocation.