Glutathione mercaptides as transport forms of metals

Among the many cellular functions of GSH, the roles of this tripeptide in metal transport, storage, and metabolism have recently received considerable attention. Although these roles had often been overlooked, they are critical for normal cellular metabolism and for protection from xenobiotics. Indeed, a number of the protective and regulatory functions of GSH are related to its ability to chelate reactive metals. GSH functions in the mobilization and delivery of metals between ligands, in the transport of metals across cell membranes, as a source of cysteine for metal binding, and as a reductant or cofactor in redox reactions involving metals. However, the interaction between GSH and metals can also produce or exacerbate cell injury. For example, GSH appears to be involved in the renal accumulation and toxicity of a number of metals, and in the carcinogenicity of chromium. Additional work is clearly needed to identify the mechanisms involved, and to better define the roles of GSH in metal homeostasis.