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Effect of macrophage activation on plasma disposition of niosomal 3H-methotrexate in sarcoma-180 bearing mice
K S Chandraprakash1, N Udupa, P Umadevi
1College of Pharmaceutical Sciences, Kasturba Medical College, Manipal, India.
Journal of Drug Targeting
|January 1, 1993
Abstract:
Methotrexate niosomes were formed by reverse phase evaporation technique using sorbitan monostearate (Span 60) surfactant. The pharmacokinetic parameters of methotrexate (MTX) after macrophage activation via muramyl dipeptide gelatin conjugate were studied and the results compared with those obtained after free MTX and MTX niosomes without macrophage activation. In mice MTX concentrations and tumour regression were higher after macrophage activation.