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[Lymphocytic subpopulations implicated in the rheumatoid rosette phenomenon]

J Sany, J Clot, H M Sip

    Revue Du Rhumatisme Et Des Maladies Osteo-Articulaires
    |May 1, 1975
    PubMed
    Summary

    Rheumatoid rosettes (RR) were studied in rheumatoid polyarthritis (RP) patients and controls. Technical factors like incubation time and temperature influenced RR. Results suggest K cells, not T or B lymphocytes, may form RR.

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    Area of Science:

    • Immunology
    • Rheumatology

    Context:

    • Rheumatoid polyarthritis (RP) is an autoimmune disease.
    • Rheumatoid rosettes (RR) are cell aggregates observed in certain conditions.
    • Understanding RR formation is crucial for diagnosing and managing autoimmune diseases.

    Purpose:

    • To investigate the phenomenon of rheumatoid rosettes (RR) in patients with rheumatoid polyarthritis (RP).
    • To identify the cell types involved in the formation of RR.
    • To explore the influence of technical factors on RR prevalence.

    Summary:

    • The study examined RR in 21 RP patients and 16 controls, noting technical factors like incubation time and temperature significantly affected RR numbers.
    • Lymphocyte separation techniques revealed that RR prevalence increased after B cell removal and was higher in B cell-rich populations, suggesting B cells are not the primary source of RR.

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  • Findings indicate that RR formation may involve K cells (lymphocytes with Fc receptors) rather than T or B lymphocytes, potentially representing an active fraction of EA rosettes.

    • Impact:

    • Provides insights into the cellular mechanisms underlying rheumatoid rosettes.
    • Suggests a potential role for K cells in the pathogenesis of rheumatoid polyarthritis.
    • Highlights the importance of standardized technical protocols for accurate RR assessment in clinical and research settings.