[Hypertension inducing cerebrovascular damage and effecting on cerebral infarction]

Cerebrovascular damage of renovascular hypertensive rats (RHR) was observed under light microscope and electron microscope, and the cerebral collateral vessels of RHR were observed with vascular casts. In focal cerebral ischemia of RHR, the infarct volume was measured by TTC staining in combination with computer image processing and analysis. When hypertension persisting longer, there were hyalinosis in small arterial walls, luminal narrowing and basement membrane thickening in capillaries, decreased collateral vessels, and occluded microvessels. In cerebral ischemia, the infarct volume was large and could not be improved. The results demonstrated that the key to prevent stroke is to prevent and treat hypertension as early as possible.