Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Shivering thermogenesis during acute hypercapnia

V Lun1, J C Sun, G G Giesbrecht

  • 1School of Kinesiology, Simon Fraser University, Burnaby, BC, Canada.

Canadian Journal of Physiology and Pharmacology
|March 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Atlantoaxial joint space and pharyngeal airway changes in skeletal class Ⅲ patients with mandibular deviation after combined orthodontic-orthognathic treatment: a cone-beam CT analysis].

Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology·2025
Same author

[Follicular dendritic cell sarcoma of the tonsil: a case report].

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery·2024
Same author

[Study on the mechanism of early pancreatic exocrine function changes in severely scalded rats].

Zhonghua shao shang yu chuang mian xiu fu za zhi·2023
Same author

Corticospinal and spinal excitability during peripheral or central cooling in humans.

Journal of thermal biology·2023
Same author

[Effects of collagen type ⅩⅦ α1 on epidermal stem cells in aging skin and the microRNA intervention mechanism].

Zhonghua shao shang yu chuang mian xiu fu za zhi·2022
Same author

[Research advances on the role and mechanism of epidermal stem cells in skin wound repair].

Zhonghua shao shang yu chuang mian xiu fu za zhi·2022
Same journal

Next-generation therapeutics and renaissance of legacy drugs targeting the endothelin system.

Canadian journal of physiology and pharmacology·2026
Same journal

Exploring the causal relationship between inflammatory cytokines and diabetic foot ulcer: A bidirectional Mendelian randomization and clinical validation study.

Canadian journal of physiology and pharmacology·2026
Same journal

TRPV1, Endocannabinoid, and Opioid Systems in Analgesia: Molecular Mechanisms and Drug Development Strategies.

Canadian journal of physiology and pharmacology·2026
Same journal

Association of stromal cell derived factor 1α and interferon-γ induced protein 10 with Fontan pathophysiology.

Canadian journal of physiology and pharmacology·2026
Same journal

Incretins for Type 2 Diabetes.

Canadian journal of physiology and pharmacology·2026
Same journal

Glucagon-like peptide 1 receptor agonists: anti-inflammatory effects in cardiovascular diseases.

Canadian journal of physiology and pharmacology·2026
See all related articles

Acute hypercapnia, a condition of high carbon dioxide levels, temporarily reduces shivering in humans during cold exposure. This suppression of shivering does not significantly impact core body temperature or overall thermal balance.

Area of Science:

  • Human Physiology
  • Environmental Medicine
  • Thermoregulation

Background:

  • Cold exposure triggers physiological responses to maintain core body temperature.
  • Shivering thermogenesis is a key mechanism for heat production during cold stress.

Purpose of the Study:

  • To investigate the effects of acute hypercapnia on human thermoregulation during cold exposure.
  • To assess the impact of elevated carbon dioxide on shivering intensity and thermal balance.

Main Methods:

  • Eight male subjects were immersed in cold water (15°C) until core temperatures reached 35°C or 1 hour elapsed.
  • During immersion, subjects inspired either air or a gas mixture with 4% CO2 for a 15-minute period.
  • Oxygen uptake and electromyographic activity (EMG) of shivering muscles were measured as indicators of thermogenesis.

Related Experiment Videos

Main Results:

  • Inhaling 4% CO2 significantly suppressed EMG activity in both masseter and trapezius muscles, indicating reduced shivering.
  • Shivering EMG was 15% lower during hypercapnia and 55% lower in the post-hypercapnic period compared to the hypercapnic period.
  • Despite shivering suppression, core esophageal temperature (Tes) remained unaffected, suggesting no significant alteration in thermal balance.

Conclusions:

  • Acute hypercapnia can transiently suppress shivering tremor in humans during cold exposure.
  • This suppression of shivering does not appear to compromise thermal balance or core temperature regulation.
  • Further research may explore the mechanisms behind this blunted shivering response.