[Risk factors of prostate cancer--a matched case-control study]

A 1:2 matched case-control study was used to determine the risk factors of prostate cancer. Twenty-seven cases of prostate cancer were matched with an equal number of other malignant tumor cases (non-urological tumor) and other urological cases (non-malignant tumor). Both study and control groups were the same in age, sex, race, and day of admission. All of these patients were treated in the First Affiliated Hospital of West China University of Medical Sciences. The questionnaire was used to survey the both groups of patients. Such data as diet, lifestyle, marital status and past history of other prostate diseases were obtained. Single factor analysis and multiple conditional logistic regression analysis were used to estimate the relative risk (RR), 95% confidence interval (95% CI) and P values. Statistical analysis was performed using the Egret, Epilog soft ware. The results were as follows: 1. Increasing dietary vitamin A was associated with a significant decrease in the risk of prostate cancer (RR = 0.948, 95% CI = 0.9309-0.9947, P = 0.029). This factor also showed dose response gradients. The relative risk was decreasing with exposure dose increasing. 2. The positive previous prostate history, such as prostatitis and benign prostate hyperplasia, increased the risk of prostate cancer (RR = 6.385, 95% CI = 1.046-38.97, P = 0.045). 3. Another finding in the widower, divorce and remarried men (RR = 4.312, 95% CI = 1.367-13.6, P = 0.013). And 4. There was no relationship between the risk of prostate cancer and dietary fat intake, vasectomy, socioeconomic status, familial malignant tumor history, smoking and alcohol consumption.(ABSTRACT TRUNCATED AT 250 WORDS)