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Related Experiment Videos

Panic disorder: treatment with valproate

C L Woodman1, R Noyes

  • 1Department of Psychiatry, University of Iowa, Iowa City 52242.

The Journal of Clinical Psychiatry
|April 1, 1994
PubMed
Summary
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Divalproex sodium shows promise in treating panic disorder. This 6-week trial found significant improvements in panic attacks and anxiety symptoms for most patients.

Area of Science:

  • Psychiatry
  • Pharmacology

Background:

  • Panic disorder is a debilitating condition.
  • Divalproex sodium is an anticonvulsant medication.

Purpose of the Study:

  • To evaluate the efficacy of divalproex sodium in treating panic disorder.
  • To assess the impact of divalproex sodium on panic attacks and anxiety symptoms.

Main Methods:

  • A 6-week open-label clinical trial involving 12 patients with DSM-III-R diagnosed panic disorder.
  • Dose titration of divalproex sodium based on clinical response and side effects.
  • Weekly assessments using Clinical Global Impressions Scale, Hamilton Rating Scale for Anxiety, panic-attack diary, and Brief Symptom Inventory.

Main Results:

  • All 12 patients completed the study with moderate to marked improvement.

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  • Significant and rapid improvements observed in panic attacks and anxiety measures.
  • Sustained improvement noted in 11 patients at 6-month follow-up.

    • Conclusions:

    • Divalproex sodium demonstrates potential efficacy in managing panic disorder.
    • Further investigation through double-blind studies is warranted to confirm these findings.