[Atherogenic properties of oral sugar-reducing sulfonylurea derivatives]

The authors have examined the effects of sulfonylurea drugs glibenclamide and glipizide and of their analogs manilil and minidiab on cholesterol levels in murine peritoneal macrophages. Both glibenclamide and glipizide had a direct atherogenic effect on cultured murine peritoneal macrophages. A similar effect was observed in vivo: blood sera of diabetics after a single intake of 5 mg of manilil or minidiab increased the atherogenic potential of cultured murine peritoneal macrophages.