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[Kidney transplants from asystolic donors]
M González Martín1, J García Buitrón, C García Freire
1Servicio de Urología, Hospital Juan Canalejo, La Coruña.
Actas Urologicas Espanolas
|May 1, 1994
Summary
Kidney transplants from donors after asystole show promising results. While acute tubular necrosis caused initial function delays, long-term graft survival rates were comparable to standard transplants.
Area of Science:
- Nephrology
- Transplantation Surgery
- Organ Donation
Background:
- Renal transplantation is a critical treatment for end-stage renal disease.
- Utilizing deceased donors after circulatory arrest (asystole) expands the donor pool.
- Evaluating outcomes of kidneys from asystolic donors is essential for expanding organ availability.
Purpose of the Study:
- To review the outcomes of renal transplantation using kidneys from donors after asystole.
- To compare graft survival and function in recipients of kidneys from asystolic donors versus standard donors.
Main Methods:
- Retrospective review of 31 renal transplantations from asystolic donors.
- Analysis of different preservation methods including cardiocompression, assisted ventilation, in situ cold perfusion, and cardiopulmonary bypass.
- Comparison with a control group of 50 standard renal transplants.
Main Results:
- Graft survival at three months was 77% for kidneys from asystolic donors.
- A 70% delay in initial graft function was observed, primarily due to acute tubular necrosis.
- No significant differences in one-year graft survival or recipient outcomes were noted compared to the control group.
Conclusions:
- Renal transplantation from asystolic donors is a viable option, offering comparable long-term outcomes.
- Acute tubular necrosis is a significant factor affecting early graft function in this donor population.
- Strategies to mitigate delayed graft function are crucial for optimizing results from asystolic donor kidneys.