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Related Experiment Videos

Memory of DL-polylactic acid biodegradable plates

H W Losken1, A Tschakaloff, R von Oepen

  • 1Division of Plastic and Reconstructive Surgery, University of Pittsburgh, PA.

Annals of Plastic Surgery
|June 1, 1994
PubMed
Summary

Biodegradable DL-polylactic acid plates exhibit shape memory properties in vivo and in vitro. Heat treatment to 200°C eliminated this memory effect, indicating potential for controlled applications in biodegradable implants.

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Area of Science:

  • Biomaterials Science
  • Polymer Science
  • Orthopedic Surgery

Background:

  • Biodegradable implants offer advantages over traditional metal devices.
  • DL-polylactic acid is a promising material for biodegradable orthopedic applications.

Purpose of the Study:

  • To investigate the shape memory properties of biodegradable DL-polylactic acid plates.
  • To assess the effect of heat treatment on these memory properties.

Main Methods:

  • Four-hole DL-polylactic acid plates were injection-molded and bent to various angles.
  • Plates were implanted subcutaneously in rabbits and observed in vitro.
  • In vitro experiments included heat tempering at 200°C.
  • Bending angles were measured after implantation and heat treatment.

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Main Results:

  • Implanted plates spontaneously straightened after two weeks, demonstrating shape memory.
  • In vitro tests confirmed the shape memory effect.
  • Heat tempering at 200°C for specified durations eliminated the memory property.
  • After four weeks, the bending angle change was less than 2.5 degrees.

Conclusions:

  • Biodegradable DL-polylactic acid plates possess inherent shape memory characteristics.
  • Controlled heat treatment can effectively negate these shape memory properties.
  • This suggests potential for tailored applications of these biodegradable materials in medical devices.