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Atopic dermatitis of infancy and urinary tract infections
Insights
Infants with atopic dermatitis (AD) have a higher risk of urinary tract infections (UTI). Treating AD and using urine antibiograms significantly reduced the recurrence of significant bacteriuria and leukocyturia (SBL) in these infants.
Area of Science:
- Pediatrics
- Dermatology
- Infectious Diseases
Background:
- Infants evaluated for atopic dermatitis (AD) showed a high prevalence of significant bacteriuria and leukocyturia (SBL).
- Routine urinalysis and urine culture with antibiograms are part of the diagnostic process for infants with AD.
Purpose of the Study:
- To investigate the potential association between atopic dermatitis (AD) and urinary tract infections (UTI) in infants.
- To determine if infants with AD have a higher incidence of UTI compared to controls.
Main Methods:
- Retrospective analysis of urine tests and cultures from 131 infants with untreated AD and 1,327 age-matched controls.
- Data included urinalysis, urine culture results, and antibiograms for infants aged 1-24 months.
Main Results:
- Significant bacteriuria and leukocyturia (SBL) was found in 27.5% of infants with AD versus 3% in controls (p < 10(-5)).
- Following AD treatment and antibiotic therapy based on urine antibiograms, the SBL recurrence rate dropped to 8.3% over 6 months.
Conclusions:
- Infants diagnosed with atopic dermatitis (AD) may face an increased risk of developing urinary tract infections (UTI).
- Effective treatment for AD, including targeted antibiotic therapy, appears to mitigate the risk and recurrence of UTI in affected infants.
Background:
Infants under evaluation for atopic dermatitis (AD) at our clinic undergo a battery of examinations that include urinalysis and urine culture tests with antibiograms. The prevalence of cases with significant bacteriuria and leukocyturia (SBL) appeared to be unexpectedly high.
Objective:
This study attempts to establish whether infants with AD should be suspected of having a higher prevalence of urinary tract infections (UTI).
Methods:
A retrospective analysis of urine and urine culture tests was performed in 131 infants (84 males and 47 females) aged 1-24 months with untreated AD and in 1,327 control subjects (621 male, 706 female) aged 1-24 months.
Results:
SBL was present in 27.5% of cases versus 3% of controls (p < 10(-5)). After routine treatment for AD and antibiotic treatment on the basis of a urine antibiogram, the recurrence rate of SBL, evaluated monthly over a 6-month period, was only 8.3%.
Conclusion:
Infants with AD might be at a greater risk for developing UTI, and when treated for AD this risk might be reduced.