Related Experiment Video
Updated: Sep 5, 2026

Targeting Gray Rami Communicantes in Selective Chemical Lumbar Sympathectomy
Published on: January 10, 2019
Phlegmasia cerulea dolens: the role of non-operative therapy
1Department of Surgery (12A3), Metropolitan Hospital Center, New York 10029.
Insights
Non-operative therapy effectively treats phlegmasia cerulea dolens, rapidly correcting ischemia and resolving edema without complications. This approach avoids risks associated with thrombectomy and thrombolysis, preserving limbs in critically ill patients.
Area of Science:
- Vascular Surgery
- Critical Care Medicine
Background:
- Phlegmasia cerulea dolens (PCD) carries a high risk of amputation and death.
- Traditional treatments like thrombectomy and thrombolysis have significant complication rates.
Purpose of the Study:
- To evaluate the efficacy and safety of non-operative therapy as a first-line treatment for PCD.
- To compare outcomes of non-operative therapy with invasive procedures.
Main Methods:
- Retrospective analysis of seven extremities in six patients with PCD treated over nine years.
- Five extremities were managed with non-operative therapy (elevation, hydration, heparinization).
- One patient had pre-existing gangrene, and one underwent emergency thrombectomy.
Main Results:
- Non-operative therapy rapidly corrected ischemia in all five treated extremities.
- Complete edema resolution occurred within 3-4 days in four patients.
- No therapy-related complications were observed; two patients died from underlying terminal illnesses.
Conclusions:
- Non-operative therapy is an effective and safe first-line treatment for phlegmasia cerulea dolens.
- It successfully prevents limb loss and avoids the complications of thrombectomy and thrombolysis.
- This approach is particularly beneficial for critically ill patients.
Abstract:
Thrombectomy and thrombolysis are often advocated in the treatment of phlegmasia cerulea dolens, but frequently result in incomplete clot removal, recurrence of thrombosis, local and systemic hemorrhagic complications and chronic venous stasis; this state is associated with a rate of major amputation and death of up to 50%. Non-operative therapy includes elevation, hydration and heparinization and excludes all methods aimed at surgical removal or chemical lysis of the thrombus. In 1982 it was decided to use non-operative therapy as the first line of treatment for phlegmasia cerulea dolens. In the last 9 years seven extremities in six patients with this condition have been treated. One patient had advanced gangrene on presentation and one underwent emergency thrombectomy. Five extremities (in five patients) were treated with non-operative therapy. Ischemia was rapidly corrected in all five patients. Edema resolved completely after 3-4 days in four patients. There were no complications attributable to the therapy. Two of six (33%) patients died from terminal disease. Non-operative therapy appears to be effective in preventing limb loss and avoiding the risks of thrombectomy and thrombolysis in critically ill patients.
Related Concept Videos
Peripheral Artery Disease III: Interprofessional Care
Peripheral Artery Disease IV: Nursing Management
Peripheral Artery Disease V: Postoperative Nursing Management
Varicose Veins II: Diagnostic Studies and Interprofessional Care
Venous Thrombosis III: Interprofessional Care
Venous Thrombosis IV: Nursing Management

