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[Fibrinolytic and thrombolytic properties of the drug morikrase]
Abstract:
Fibrinolytic and thrombolytic properties of morikrase, a complex of proteinases obtained from hepatopancreatic tissues of king crab (Paralithodes camtschatica), were studied in vivo and in vitro. High fibrinolytic activity and dose-dependent activating properties were detected on standard and heated fibrin plates. The preparation maintained its properties during long-term storage at 4 degrees and 22 degrees C. The thrombolytic activity of the drug, affecting the preformed thrombus, was observed both in vitro and in vivo, in rats with experimental thrombosis. Two-phase alteration of the fibrinolytic system and moderate hypocoagulation were found after intravenous administration of morikrase.
Insights
Morikrase, a king crab proteinase complex, demonstrates significant fibrinolytic and thrombolytic activity. This preparation effectively dissolves blood clots and maintains stability, showing potential for therapeutic applications.
Area of Science:
- Biochemistry
- Pharmacology
- Marine Biology
Context:
- Investigating novel therapeutic agents from natural sources.
- Assessing the properties of proteinases from king crab (Paralithodes camtschatica).
Purpose:
- To evaluate the fibrinolytic and thrombolytic potential of morikrase.
- To determine the stability and in vivo/in vitro efficacy of morikrase.
Summary:
- Morikrase exhibits high fibrinolytic activity on fibrin plates and dose-dependent activation.
- The preparation demonstrated thrombolytic effects on preformed thrombi in vitro and in vivo (rats).
- Morikrase showed stability during long-term storage and induced a two-phase alteration in the fibrinolytic system with moderate hypocoagulation post-administration.
Impact:
- Morikrase shows promise as a novel therapeutic agent for thrombotic disorders.
- The study highlights the potential of marine-derived enzymes in pharmaceutical development.
- Findings contribute to understanding the mechanisms of fibrinolysis and thrombolysis.