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Related Experiment Videos

Dietary protection during radiation therapy

G Bounous, E Le Bel, J Shuster

    Strahlentherapie
    |May 1, 1975
    PubMed
    Summary
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    A semi-hydrolyzed diet (Flexical) helped cancer patients maintain body weight and immune status during Cobalt 60 irradiation, reducing diarrhea and lymphocyte loss compared to a normal diet.

    Area of Science:

    • Oncology
    • Radiotherapy
    • Nutrition Science

    Background:

    • Cancer patients undergoing radiotherapy often experience malnutrition and side effects like diarrhea.
    • Maintaining nutritional and immunological status is crucial for treatment tolerance and outcomes.

    Purpose of the Study:

    • To evaluate the impact of a semi-hydrolyzed diet (Flexical) versus a normal diet on cancer patients receiving Cobalt 60 irradiation.
    • To assess nutritional status, body weight, and immunological markers during radiotherapy.

    Main Methods:

    • Eighteen patients with abdominal or pelvic malignancies were randomized to receive either Flexical or a normal diet during Cobalt 60 irradiation.
    • Key parameters monitored included body weight, serum proteins, immunoglobulins, and blood cell counts.

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    Main Results:

    • The Flexical group showed a significant positive effect on body weight and no radiation-induced diarrhea.
    • Serum proteins and immunoglobulins remained stable in the Flexical group, unlike the control group.
    • A significantly smaller drop in blood lymphocytes was observed in patients on the Flexical diet.

    Conclusions:

    • A semi-hydrolyzed diet may help maintain nutritional and immunological status in cancer patients undergoing intensive irradiation.
    • Dietary interventions like Flexical show potential for radioprotection and mitigating treatment side effects.