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Complications of corticosteroid therapy
C Talar-Williams1, M C Sneller
1Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
Summary
This review covers corticosteroid biochemistry and pharmacology for clinical use, including head and neck diseases. Alternate-day therapy is emphasized for long-term management of inflammatory and autoimmune disorders.
Area of Science:
- Biochemistry
- Pharmacology
- Clinical Medicine
Background:
- Corticosteroids are vital in treating various diseases.
- Understanding their mechanisms is key for effective application.
- Head and neck conditions represent a significant area of corticosteroid use.
Purpose of the Study:
- To review the biochemistry and pharmacology of corticosteroids.
- To discuss their clinical applications, particularly in head and neck diseases.
- To provide guidance on dosage regimens and complication management.
Main Methods:
- Literature review of corticosteroid biochemistry and pharmacology.
- Analysis of clinical applications and therapeutic strategies.
- Discussion of complications and management protocols.
Main Results:
- Corticosteroids exhibit complex biochemical and pharmacological profiles.
- Effective clinical use requires understanding of these profiles.
- Alternate-day therapy is a key strategy for long-term management, minimizing side effects.
Conclusions:
- Corticosteroids are essential therapeutic agents.
- Optimized dosage regimens, including alternate-day therapy, improve patient outcomes.
- Careful management of complications is crucial for safe and effective corticosteroid use.