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Hypercalcemia, monoclonal protein, and osteolytic bone lesions in chronic lymphocytic leukemia
M Van de Casteele1, G E Verhoef, H Demuynck
1University Hospital Gasthuisberg, Leuven, Belgium.
Annals of Hematology
|August 1, 1994
Abstract:
We describe a patient with a long history of typical chronic lymphocytic leukemia (CLL) who developed hypercalcemia, osteolytic bone lesions, and a monoclonal protein, all features of a secretory plasma cell disorder. These features in CLL have been reported in only four previous cases. The hypercalcemia in our patient is felt to result from an increase in the osteoclastic process.