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Hb Nottingham or alpha 2 beta 2 98 (FG5) Val-->Gly in a Czech child
V Brabec1, K Indrák, H Fortová
1Institute of Hematology and Blood Transfusion, Prague, Czech Republic.
Annals of Hematology
|August 1, 1994
Abstract:
We report a fourth case of Hb Nottingham [alpha 2 beta 2 98 (FG5) Val-->Gly] observed in an 8-year-old girl in the Czech Republic with clinical and laboratory symptoms of severe hemolytic anemia. The unstable hemoglobin probably represents a de novo mutation, since the parents of the patient and the two siblings do not exhibit any hematological abnormalities. Splenectomy had a beneficial effect on the degree of hemolysis, as well as on the Hb level.