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Gliomas in patients with acquired immune deficiency syndrome
1Department of Neurosciences, University of California, San Diego 92103-0812.
Background:
Ten percent of patients with acquired immune deficiency syndrome (AIDS) have intracerebral mass lesions of which the majority are due either to toxoplasmosis or primary central nervous system lymphomas.
Methods:
Three patients with AIDS presented with solitary intracerebral mass lesions and were found by pathologic examination to have gliomas.
Results:
After surgery, all patients were treated with radiotherapy and procarbazine, comustine, and vincristine multiagent chemotherapy. Median follow-up is 12 months.
Conclusions:
Occasionally, patients with AIDS and intracerebral mass lesions have primary nonlymphomatous brain tumors, an occurrence not related clearly to underlying immunoincompetence.