Electrophysiological studies of nerve and muscle in comparative neoplasia

The purpose of this study was to test the effect of tumor on neuromuscular function in rats and to compare the neoplastic neuro-myopathy in patients with the animal model. In the I experimental part were performed: EMG examination, motor nerve conduction velocity and membrane resting potential defining, test with repetitive supramaximal stimulation and measurement of the muscle weight on rats with transplanted epithelioma Guérin (EG) as well as with benzopyrene induced fibrosarcoma (Sa). II Clinical part was carried out in patients with neoplasma using routine electrophysiological methods. The results obtained in the I part indicate the neurogenic atrophy of the muscle, progressing with tumor development. The pathological signs were much more expressed in E.G. group than in Sa group. In the II part it was found the decrease of sensory nerve's excitability and of EMG surface. Concluding the transplantable tumor (EG) influence in rats neuromyopathy with the destruction of the whole motor unit. They are strict relations between the findings observed in E.G. rats and those reported in patients with neoplastic disease.