Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Corticosteroids in brain tissue

B J Carroll, B Heath, D B Jarrett

    Endocrinology
    |August 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Brain corticosteroid levels are lower than plasma but higher than unbound plasma levels across species. Mouse brains show circadian variation and stress response, with levels decreasing post-mortem.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A proof of concept case series of botulinum toxin a treatment for ischemic feet due to Raynaud's phenomenon.

    Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2026
    Same author

    Simulations and measurements of bilamellar streak tubes.

    The Review of scientific instruments·2022
    Same author

    Sulodexide in venous disease.

    Journal of thrombosis and haemostasis : JTH·2018
    Same author

    A genome-wide association study of antidepressant response in Koreans.

    Translational psychiatry·2015
    Same author

    Clinical science and biomarkers: against RDoC.

    Acta psychiatrica Scandinavica·2015
    Same author

    A genome-wide association study of antidepressant response in Koreans.

    Translational psychiatry·2015
    Same journal

    Loss of the calorie restriction response protein DEPP1 worsens diet-induced obesity.

    Endocrinology·2026
    Same journal

    Long Non-Coding RNAs Mediate Endocrine Signaling and Resistance in Prostate Cancer.

    Endocrinology·2026
    Same journal

    Repeated Chemogenetic Activation of C1 Catecholamine Neurons Reduces Subsequent Glucoprivic Responses and Mimics HAAF.

    Endocrinology·2026
    Same journal

    Postnatal exposure to maternal hypothyroidism leads to developmental delay and metabolic dysregulations in male mice.

    Endocrinology·2026
    Same journal

    Discovery proteomics identification of factors contributing to gonadotropin β expression.

    Endocrinology·2026
    Same journal

    3D genome architecture and epigenetic regulation of lineage identity in advanced prostate cancer.

    Endocrinology·2026
    See all related articles

    Area of Science:

    • Neuroendocrinology
    • Comparative Physiology
    • Biochemistry

    Background:

    • Corticosteroids play crucial roles in physiological regulation.
    • Understanding corticosteroid distribution in the brain is vital for neurological research.
    • Previous studies have focused on plasma levels, with limited data on brain concentrations across species.

    Purpose of the Study:

    • To quantify total corticosteroid concentrations in the plasma and brains of five species.
    • To investigate the relationship between plasma and brain corticosteroid levels.
    • To explore diurnal variations and stress responses of brain corticosteroids in mice.

    Main Methods:

    • Validated competitive protein binding techniques for tissue corticosteroid assays.
    • Measured corticosteroid concentrations in plasma and brain tissue of mice, rats, cats, monkeys, and humans.

    Related Experiment Videos

  • Assessed liver corticosteroid levels in mice, rats, and monkeys.

    • Main Results:

    • Brain corticosteroid levels were consistently lower than total plasma levels but exceeded the unbound plasma fraction in all species.
    • Mice exhibited significant circadian variation in brain corticosteroid levels and rapid elevation under stress.
    • Adrenalectomy and dexamethasone treatment reduced both plasma and tissue corticosteroid concentrations in mice; post-mortem levels declined significantly.

    Conclusions:

    • Brain corticosteroid concentrations are distinct from plasma levels, suggesting active transport or local synthesis.
    • The brain's corticosteroid system in mice demonstrates dynamic regulation in response to circadian rhythms and stress.
    • Corticosteroids are widely distributed in various brain regions across species, irrespective of direct involvement in pituitary-adrenocortical regulation.