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Nucleotide sequence of the cDNA encoding human helix-loop-helix Id-1 protein: identification of functionally
R W Deed1, M Jasiok, J D Norton
1CRC Department of Gene Regulation, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.
Biochimica Et Biophysica Acta
|September 13, 1994
Abstract:
We have determined the cDNA sequence encoding a 154 amino acid human Id-1 helix-loop-helix protein. Comparison with the amino acid sequences of human and mouse Id-2 and Id-3 proteins, reveals conservation/divergence of several residues in the helix-loop-helix domain known to be important for heterodimerisation, together with a common casein kinase II phosphorylation site.