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[Insulin allergy in type II diabetes: rapid desensitization]
E Ruíz Barrera1, S Martínez-Cario Cueto
1Departamento de inmunología clínica y alergia, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, México.
Revista Alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)
|January 1, 1994
Summary
Patients with insulin allergy experienced systemic reactions like rash and angioedema. Skin tests confirmed insulin allergy, enabling continued insulin use without adverse effects.
Area of Science:
- Allergy and Immunology
- Endocrinology
Background:
- Insulin allergy is a rare but significant concern for diabetic patients.
- Previous drug allergies may predispose individuals to insulin hypersensitivity.
Observation:
- Eight patients (7 female, 1 male, aged 49-68) with diagnosed insulin allergy were studied.
- Seven patients had a history of allergies to penicillin, sulfa drugs, or nalidixic acid.
- Predominant clinical manifestations included rash, angioedema, hypotension, and bronchial spasm.
Findings:
- All 8 patients showed positive results in skin tests for insulin allergy.
- One patient had a positive local skin reaction, while seven had positive systemic reactions.
- Successful desensitization allowed for continued insulin administration without further adverse reactions.
Implications:
- Skin testing is a valuable diagnostic tool for insulin allergy.
- Effective management strategies exist for patients with insulin hypersensitivity.
- Further research into the mechanisms of insulin allergy is warranted.