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Related Experiment Videos

Perfluorochemical liquid as a respiratory medium

T H Shaffer1, M R Wolfson, J S Greenspan

  • 1Department of Physiology, Temple University School of Medicine, Philadelphia, PA.

Artificial Cells, Blood Substitutes, and Immobilization Biotechnology
|January 1, 1994
PubMed
Summary
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Perfluorochemical (PFC) liquid ventilation offers improved oxygenation and CO2 removal for immature or injured lungs. This approach is now being investigated as a therapy for severe respiratory distress in human infants.

Area of Science:

  • Biomedical Engineering
  • Respiratory Physiology

Background:

  • Perfluorochemical (PFC) liquids have been explored for decades to support respiration.
  • Their properties allow gas exchange at lower pressures, benefiting immature or injured lungs.

Purpose of the Study:

  • To summarize the physiological principles and applications of liquid ventilation (LV).
  • To present results from initial investigational clinical studies of LV in human neonates.

Main Methods:

  • Review of physiological principles of PFC liquid ventilation.
  • Summary of experimental work in animal models (premature, lung injury).
  • Analysis of initial clinical studies in human neonates with respiratory distress.

Main Results:

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  • Liquid PFCs provide adequate oxygenation and CO2 removal with low insufflation pressures.
  • LV homogeneously inflates the lung, improving ventilation/perfusion (V/Q) matching.
  • Opaque PFC liquids serve as effective high-resolution computed tomographic (HRCT) bronchographic contrast agents.

    • Conclusions:

    • Liquid ventilation with PFCs is a promising investigational therapy for severe respiratory distress in neonates.
    • PFCs facilitate gas exchange and can be used for drug delivery and advanced imaging.