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Lithium determinations evaluated in eight analyzers

M Sampson1, M Ruddel, R J Elin

  • 1Clinical Pathology Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892.

Clinical Chemistry
|June 1, 1994
PubMed
Summary
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Five ion-selective electrodes (ISEs) and a colorimetric method were compared for lithium determination. Baxter, Beckman, and Corning ISEs demonstrated the closest results to flame atomic emission spectroscopy, showing good precision and recovery.

Area of Science:

  • Clinical Chemistry
  • Analytical Chemistry
  • Biomedical Instrumentation

Background:

  • Accurate lithium determination is crucial for therapeutic drug monitoring.
  • Various analytical methods exist for lithium measurement, each with potential limitations.

Purpose of the Study:

  • To compare the performance of five ion-selective electrodes (ISEs) and one colorimetric method for lithium determination.
  • To evaluate precision, recovery, and interference from drugs and inorganic analytes.

Main Methods:

  • Comparison of AVL 985S, Baxter Lytening 2Z, Beckman EL-ISE, Ciba-Corning 654 Na/K/Li, and Nova CRT 11 ISEs against Ektachem colorimetric method.
  • Assessment using flame atomic absorption and atomic emission spectroscopy as reference methods.
  • Evaluation of interference from common drugs and inorganic analytes (Na, K, Ca, Mg, Br).

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Main Results:

  • Imprecision was <5% (CV) for most analyzers, excluding Ektachem and Beckman.
  • Analytical recovery was within 100% +/- 5% for most, excluding Ektachem and Baxter.
  • Baxter, Beckman, and Corning ISEs showed the closest agreement with flame atomic emission spectroscopy.

Conclusions:

  • Baxter, Beckman, and Corning ISEs are reliable for lithium determination with minimal interference.
  • Some ISEs and the colorimetric method exhibited significant interference from drugs and inorganic analytes.
  • Method selection should consider potential interferences and desired accuracy for lithium monitoring.