Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Hyperparathyroidism with lithium]

T Brochier1, J Adnet-Kessous, M Barillot

  • 1Service Hospitalo-Universitaire de Santé Mentale et de Thérapeutique, Centre Hospitalier Sainte-Anne, Paris.

L'Encephale
|May 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Brain Charts for the Rhesus Macaque Lifespan.

bioRxiv : the preprint server for biology·2024
Same author

Comparative phase shifting holographic interferometry.

Applied optics·2010
Same author

Simultaneous recording of macaque premotor and primary motor cortex neuronal populations reveals different functional contributions to visuomotor grasp.

Journal of neurophysiology·2007
Same author

A cortico-cortical mechanism mediating object-driven grasp in humans.

Proceedings of the National Academy of Sciences of the United States of America·2005
Same author

Patterns of muscle activity underlying object-specific grasp by the macaque monkey.

Journal of neurophysiology·2004
Same author

Investigation into non-monosynaptic corticospinal excitation of macaque upper limb single motor units.

Journal of neurophysiology·2001
Same journal

Measuring antidepressant side effects in military personnel - Clinical validation of the French version of the UKU-SERS-Pat Scale: A comparative study of patient and clinician ratings.

L'Encephale·2026
Same journal

[Empowerment in addictology].

L'Encephale·2026
Same journal

Evaluation of the links between smoking and conspiracy mentality.

L'Encephale·2026
Same journal

Use of a relevance assessment tool in therapeutic residential care: A real world study.

L'Encephale·2026
Same journal

Prevalence and characteristics of domestic violence in a sample of adult psychiatric outpatients: A cross-sectional study.

L'Encephale·2026
Same journal

From representations to practice: how professionals describe supporting parents with psychiatric or somatic illness or disability.

L'Encephale·2026
See all related articles

Long-term lithium carbonate therapy for mood disorders may induce hyperparathyroidism. Monitoring parathyroid function is crucial for patients on lithium to ensure treatment effectiveness and manage potential endocrine dysfunction.

Area of Science:

  • Endocrinology and Pharmacology
  • Biochemical Regulation
  • Mineral Metabolism

Context:

  • Lithium carbonate is a widely used mood stabilizer for long-term treatment of affective disorders.
  • Hyperparathyroidism is a potential, though not fully understood, side effect of lithium therapy.
  • Previous reports include case studies and cross-sectional analyses of calcium metabolism.

Purpose:

  • To investigate the causal relationship between lithium treatment and hyperparathyroidism.
  • To elucidate the underlying mechanisms of lithium-induced endocrine dysfunction.
  • To provide recommendations for monitoring and managing parathyroid function in patients on lithium.

Summary:

  • Lithium may induce hyperparathyroidism through mechanisms involving altered parathyroid hormone (PTH) secretion and sensitivity to calcium.

Related Experiment Videos

  • Observed metabolic features include low serum phosphate, high serum chloride, increased serum magnesium, and low urinary calcium.
  • In vitro studies suggest lithium inhibits hormone-responsive adenylcyclase systems, potentially explaining observed metabolic abnormalities.

    • Impact:

    • Understanding lithium's effect on parathyroid function is vital for maintaining lithium's therapeutic efficacy in mood disorders.
    • Early detection and management of hyperparathyroidism can prevent complications and optimize patient care.
    • Recommendations for pre-treatment screening and periodic monitoring of calcium levels are proposed for patients on lithium therapy.