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Induced eye infection in rat with Staphylococcus aureus
O Famurewa1, A Pervanidis, H G Sonntag
1Department of Ophthalmology, University of Heidelberg, Germany.
Indian Journal of Pathology & Microbiology
|January 1, 1994
Summary
This study assessed Staphylococcus aureus HI/F-20 pathogenicity in mice and rats. Hematogenous ocular infection caused endophthalmitis, while transcorneal infection led to reversible anterior chamber changes.
Area of Science:
- Ophthalmology
- Microbiology
- Pathology
Background:
- Staphylococcus aureus is a common pathogen with various infection potentials.
- Understanding its ocular pathogenicity is crucial for effective treatment strategies.
Purpose of the Study:
- To evaluate the pathogenicity of Staphylococcus aureus strain HI/F-20.
- To investigate the mechanisms and outcomes of ocular infections induced by this strain in a rat model.
Main Methods:
- Pathogenicity was assessed by infecting pathogen-free mice with Staphylococcus aureus HI/F-20.
- Ocular infection in rats was induced via transcorneal injection and catheterized common carotid artery.
- Histological examination confirmed infection-induced changes.
Main Results:
- Transcorneal infection caused reversible anterior chamber changes, likely due to tissue trauma.
- Hematogenous infection via the carotid artery led to endophthalmitis, characterized by retinochoroidal edema and hyperemia.
- Staphylococcus aureus strain HI/F-20 demonstrated significant pathogenicity in the ocular models.
Conclusions:
- Hematogenous spread of Staphylococcus aureus can cause severe endophthalmitis.
- Transcorneal inoculation may result in less severe, reversible ocular surface and anterior chamber inflammation.
- The study highlights the distinct pathogenic effects of Staphylococcus aureus depending on the route of ocular infection.