Related Experiment Video
Updated: Aug 13, 2026
Observing and Quantifying Fibroblast-mediated Fibrin Gel Compaction
Published on: January 16, 2014
The Fibrel mechanism of action study. A preliminary report
1Gold Skin Care Center, Nashville, TN 37205.
Background:
Fibrel is a medical implant device that has demonstrated use in the correction of cutaneous depressions from acne scars and wrinkles.
Objective:
Mechanisms of actions have been proposed that have theorized the production of new collagen over time as a result of the Fibrel implant. The present study utilized human volunteers to study the histologic response of Fibrel over time.
Methods:
Fibrel was injected into tattoo sites behind the ears of human volunteers; skin biopsies were taken at various time intervals and studied histologically by a clinical pathologist.
Results:
An overall increase over time was noted with regard to production of collagen and inflammatory response. No change in elastic tissue was found.
Conclusions:
Fibrel does promote new collagen synthesis and inflammatory response and thus is useful to correct cutaneous depressions via soft tissue augmentation.
More Related Videos
10:26Bladder Smooth Muscle Strip Contractility as a Method to Evaluate Lower Urinary Tract Pharmacology
Published on: August 18, 2014
08:33A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers
Published on: January 5, 2024
