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Linkage analysis on complex pedigrees by simulation
1School of Mathematical Sciences, University of Bath, UK.
IMA Journal of Mathematics Applied in Medicine and Biology
|January 1, 1994
Abstract:
A Markovian scheme for simulating the genotypes of individuals in a pedigree subject to constraints imposed by observed phenotypes is used to estimate the logarithm of a likelihood ratio in linkage analysis. The method is illustrated on a fictitious pedigree by comparison with exactly calculated results.