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[The virus-inhibiting activity of a preparation obtained from a mussel hydrolysate]
Abstract:
Antiviral properties were found with a preparation obtained from mussel meat by acid hydrolysis. In the experiments in vitro this mussel hydrolysate reduced the infectious activity of influenza viruses in neutralization tests by 3-6 log. Applications of the preparation to mice infected with a toxigenic influenza virus strain protected from death 66-84% of the animals, the survival rate in controls being from 9 to 16%. The protective effect of mussel hydrolysate was observed both after intranasal and oral administrations. The optimal protective effect was obtained when the preparation was used 5-24 hours before inoculation.
Insights
Mussel hydrolysate exhibits potent antiviral properties against influenza viruses. This natural preparation significantly reduces viral activity and protects infected mice from death, offering a promising therapeutic avenue.
Area of Science:
- Marine biotechnology
- Virology
- Immunology
Background:
- Emerging viral infections pose a significant global health threat.
- Natural products are increasingly investigated for therapeutic potential.
- Mollusks are a source of bioactive compounds with diverse properties.
Purpose of the Study:
- To investigate the antiviral activity of a mussel hydrolysate preparation.
- To evaluate the efficacy of mussel hydrolysate against influenza viruses in vitro and in vivo.
- To determine optimal administration routes and timing for the mussel hydrolysate.
Main Methods:
- Acid hydrolysis of mussel meat to obtain the preparation.
- In vitro neutralization tests to assess reduction in influenza virus infectious activity.
- In vivo studies using a toxigenic influenza virus strain in mice.
- Evaluation of survival rates following intranasal and oral administration of the hydrolysate.
Main Results:
- Mussel hydrolysate demonstrated significant reduction of influenza virus infectious activity (3-6 log) in vitro.
- In vivo administration protected 66-84% of infected mice from death, compared to 9-16% in controls.
- Protective effects were observed with both intranasal and oral administration routes.
- Optimal protection was achieved when the hydrolysate was administered 5-24 hours prior to infection.
Conclusions:
- Mussel hydrolysate possesses significant antiviral properties against influenza.
- The preparation offers a protective effect against influenza infection in a mouse model.
- Further research into mussel-derived compounds for antiviral therapies is warranted.