Related Experiment Video
Updated: Jul 31, 2026

Diagonal Method to Measure Synergy Among Any Number of Drugs
Published on: June 21, 2018
A comparison of drug interaction software programs: applicability to the emergency department
R M Goldberg1, J Mabee, M Mammone
1Department of Emergency Medicine, Los Angeles County/University of Southern California Medical Center.
This study evaluated drug interaction software for emergency departments (EDs). While no program was perfect, many offer useful features for the fast-paced ED environment.
Area of Science:
- Clinical Informatics
- Pharmacology
- Emergency Medicine
Background:
- Effective drug interaction software is crucial for patient safety in emergency settings.
- Emergency departments (EDs) face unique challenges requiring specialized clinical tools.
Purpose of the Study:
- To compare features of available drug interaction software.
- To assess general applicability for emergency department (ED) use.
Main Methods:
- Prospective evaluation of eight commercial drug interaction software programs.
- Assessment based on the presence or absence of key performance features.
- Evaluation conducted in university and community hospital EDs.
Main Results:
- Programs were assessed using predefined performance and database features.
- Tabulated results facilitated direct comparison across software.
- No single program fully met all specific ED needs.
Conclusions:
- Several drug interaction software programs possess features applicable to ED settings.
- Ongoing development may lead to more tailored solutions for emergency care.
Related Concept Videos
Combined Effects of Drugs: Synergism
Such synergistic combinations...
Agonism and Antagonism: Quantification
To quantify these effects, researchers use a dose-response curve, which provides valuable information about the potency and efficacy of a drug. Potency refers to...
Pharmacokinetics: Drug–Drug Interactions
Pharmacokinetic–Pharmacodynamic Relationship: Problems
Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions
Drug toxicity: Drug–Drug Interaction

