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Fluoxetine abuse

J A Tinsley1, M W Olsen, R R Laroche

  • 1Department of Psychiatry and Psychology, Mayo Clinic Rochester, MN 55905.

Mayo Clinic Proceedings
|February 1, 1994
PubMed
Summary
This summary is machine-generated.

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This report details two cases of fluoxetine (antidepressant) abuse in patients with prior substance abuse histories. Discontinuation led to improved mentation, suggesting craving and behavioral factors may be involved.

Area of Science:

  • Pharmacology
  • Psychiatry
  • Clinical Toxicology

Background:

  • Selective serotonin reuptake inhibitors (SSRIs) like fluoxetine are widely prescribed.
  • Substance abuse is a significant public health concern.
  • Understanding the potential for misuse of prescribed medications is crucial.

Observation:

  • Two patients with a history of substance abuse exhibited fluoxetine abuse.
  • Excessive dosages and concurrent drug use were noted.
  • Stimulant effects of fluoxetine were observed.

Findings:

  • Hospitalization enabled discontinuation of fluoxetine.
  • Patients showed improvement in mentation after stopping fluoxetine.
  • The exact mechanism remains unclear.

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Implications:

  • Fluoxetine abuse can occur in susceptible individuals.
  • Behavioral and craving factors may contribute to antidepressant misuse.
  • Further research into the neurobiological underpinnings of antidepressant misuse is warranted.