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Related Experiment Videos

Cocaine tolerance and cross-tolerance

J L Katz1, J W Griffiths, L G Sharpe

  • 1Psychobiology Laboratory, National Institute on Drug Abuse Addiction Research Center, Baltimore, Maryland.

The Journal of Pharmacology and Experimental Therapeutics
|January 1, 1993
PubMed
Summary
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Rats developed modest tolerance to cocaine

Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • Cocaine tolerance can alter its behavioral effects.
  • Understanding these mechanisms is crucial for addiction research.

Purpose of the Study:

  • To investigate the pharmacological mechanisms of cocaine tolerance.
  • To assess cross-tolerance to various dopaminergic drugs.

Main Methods:

  • Rats were trained on a fixed-ratio schedule for food reinforcement.
  • Cocaine (10 mg/kg, i.p.) was administered daily to induce tolerance.
  • Dose-effect curves and receptor binding assays were performed.

Main Results:

  • Cocaine treatment produced a modest rightward shift in its dose-effect curve.

Related Experiment Videos

  • Cross-tolerance was observed with WIN 35,428 but not GBR 12909.
  • No significant changes in dopamine, serotonin, or norepinephrine receptor binding were found.

    • Conclusions:

    • Cocaine tolerance does not induce significant functional or metabolic changes in dopaminergic systems.
    • Differences in mechanisms exist among dopamine uptake inhibitors.