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The effect of vpu on HIV-1-induced syncytia formation
X J Yao1, S Garzon, F Boisvert
1Département de Microbiologie et Immunologie, Faculté de Médecine, Université de Montréal, Quebec, Canada.
Journal of Acquired Immune Deficiency Syndromes
|February 1, 1993
Abstract:
To investigate the role of vpu in the cytopathicity of human immunodeficiency type 1 (HIV-1), the MT4 CD4+ T-cell line was infected with viruses that were isogenic except for their ability to produce the vpu protein. The experiments described here demonstrate that expression of vpu reduces HIV-1 cytopathic effects by decreasing the rate of syncytia formation. By reducing the concentration of gp 120 at the cell surface, vpu limits cell killing by syncytia formation.