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Updated: Jul 30, 2026
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Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Sedation and analgesia for gastrointestinal endoscopy
S Chokhavatia1, L Nguyen, R Williams
1Department of Internal Medicine (Gastroenterology Division), Texas Tech University Health Science Center, Lubbock.
The American Journal of Gastroenterology
|March 1, 1993
Summary
Meperidine combined with midazolam provided superior patient comfort and amnesia during colonoscopy compared to other opioids. Sedation and analgesia were comparable for upper gastrointestinal endoscopy, with faster recovery for alfentanil and sufentanil.
Area of Science:
- Gastroenterology
- Anesthesiology
- Pharmacology
Background:
- Gastrointestinal endoscopy requires effective sedation and analgesia.
- Opioid selection impacts patient experience and recovery.
- Midazolam is commonly used, but opioid adjuncts vary.
Purpose of the Study:
- To compare the efficacy and safety of four different opioids (meperidine, fentanyl, sufentanil, alfentanil) combined with midazolam for gastrointestinal endoscopy.
- To evaluate sedation, analgesia, amnesia, and recovery times associated with each opioid regimen.
Main Methods:
- A comparative study involving patients undergoing upper or lower gastrointestinal endoscopy.
- Patients received midazolam plus one of four opioids at specified doses, with options for additional medication.
- Outcomes assessed included sedation and analgesia scores, patient comfort, amnesia, and recovery time.
Main Results:
- No significant adverse events were observed across all groups.
- Sedation and analgesia were comparable for upper endoscopy.
- Meperidine demonstrated higher rates of amnesia and patient comfort during colonoscopy, though recovery was longer.
- Alfentanil and sufentanil were associated with shorter recovery times.
Conclusions:
- Meperidine offers advantages in patient comfort and amnesia for colonoscopy.
- Opioid choice should be tailored to the specific endoscopic procedure and patient needs.
- Further research may explore optimizing opioid combinations for enhanced endoscopic procedures.
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