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[Bile composition and antibiotic excretion. Observations with T-drainage]
R J Rosenthal1, S D Steigerwald, H Bockhorn
1Chirurgische Klinik des Krankenhauses Nordwest, Frankfurt am Main.
Zeitschrift Fur Die Gesamte Innere Medizin Und Ihre Grenzgebiete
|January 1, 1993
Summary
This study found that patients with normal bilirubin levels excreted more bilirubin in bile than those with high levels. Liver cell damage significantly reduced mezlocillin excretion in patients with elevated bilirubin.
Area of Science:
- Hepatology
- Pharmacology
- Biliary Physiology
Background:
- Bilirubin and mezlocillin are actively secreted into bile.
- Liver cell integrity impacts biliary excretion of substances.
- Serum bilirubin levels can indicate liver function.
Purpose of the Study:
- To investigate the relationship between serum bilirubin levels and biliary excretion of bilirubin and mezlocillin.
- To assess the impact of liver cell damage on mezlocillin biliary secretion.
Main Methods:
- Bile was collected from patients via T-drainage or percutaneous drainage.
- Concentrations of GGT, AP, bilirubin, and mezlocillin in bile were analyzed.
- Patients were grouped based on serum bilirubin concentration (normal vs. high).
Main Results:
- Patients with normal serum bilirubin showed significantly higher biliary bilirubin excretion compared to those with high levels.
- Maximum biliary bilirubin excretion occurred at 4 hours post-administration.
- Biliary mezlocillin concentration increased as bilirubin concentration decreased.
- Patients with pathologically elevated bilirubin levels exhibited 50-fold lower mezlocillin excretion than normal patients due to liver cell destruction.
Conclusions:
- Serum bilirubin levels are inversely correlated with biliary mezlocillin excretion.
- Liver cell damage significantly impairs the biliary excretion of mezlocillin.
- Biliary excretion patterns differ based on liver function status.