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Related Experiment Videos

Isosorbide dinitrate. Effect on the vasodilator response to nitroglycerin

R Zelis, D T Mason

    JAMA
    |October 13, 1975
    PubMed
    Summary
    This summary is machine-generated.

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    Long-term use of isosorbide dinitrate diminishes nitroglycerin

    Area of Science:

    • Cardiovascular Pharmacology
    • Clinical Pharmacology

    Background:

    • Nitroglycerin and isosorbide dinitrate are vasodilators used to treat angina.
    • Cross-tolerance between these drugs may affect their efficacy.

    Purpose of the Study:

    • To investigate potential cross-tolerance to the circulatory effects of isosorbide dinitrate and nitroglycerin.

    Main Methods:

    • Six subjects received sustained-action isosorbide dinitrate (120 mg/day) for 6-8 weeks.
    • Nitroglycerin's effects on calf blood flow and venous volume were measured before and during isosorbide dinitrate treatment.

    Main Results:

    • Nitroglycerin's venodilation effect was significantly attenuated after long-term isosorbide dinitrate administration.
    • Arteriolar dilation by nitroglycerin remained unaffected.

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    Conclusions:

    • Long-term isosorbide dinitrate use induces tolerance to nitroglycerin's venodilating effects.
    • This suggests cross-tolerance may impact the clinical utility of these nitrates.