Gastric acid secretion and intragastric acidity: measurement in health and disease

Gastric acid secretion tests have limited use in clinical practice. For practical purposes, a pH measurement on a fasting gastric aspirate will provide strong evidence of the presence or absence of achlorhydria. Tests of gastric acidity, in particular 24-h acidity studies, have provided considerable insight into normal and abnormal gastric physiology, and have largely determined the dosing regimens for the management of acid-peptic diseases. Acid tests may be simple to perform, so much so that they have been suggested as 'practicals' for student teaching (Nicol et al, 1991). However, reproducible and meaningful results require careful attention to detail, and the appropriate mathematical analysis is still subject to some debate. It is important that the presentation of the data should allow the reader to assess the response over the 24-h period, and also the range of individual responses. Despite the many years of research into gastric acid secretion, only recently have the effects of age, sex, diet, smoking and mental stress been identified. In addition, many data need to be reviewed in the light of the effects of H. pylori infection on gastrin release. H2-receptor antagonists had been studied extensively before and since their first clinical use in 1974, but surprisingly only recently have the issues of tolerance and rebound been defined. The 24-h intragastric acidity profile remains an essential study before the start of clinical trials on any new drug to be used for the treatment of acid-peptic diseases.