Related Experiment Videos
The synthesis of trans-3,4-bis-(3,4-dihydroxyphenyl)pyrrolidine, a novel DA1 agonist
T Hoshiko1, H Ishihara, M Shino
1Eisai Tsukuba Research Laboratories, Ibaraki, Japan.
Chemical & Pharmaceutical Bulletin
|March 1, 1993
Abstract:
The synthesis of trans-3,4-bis-(3,4-dihydroxyphenyl)pyrrolidine by the Michael reaction of esterenolate with nitro olefin is described. This compound was expected to be the agonist toward dopamine (DA1) receptor with equipotent affinity and to be more selective than dopamine itself.