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Effects of subcutaneous bethanechol on bladder sensation during cystometry
1Department of Urology, University of Arkansas for Medical Sciences, Little Rock.
Urology
|May 1, 1993
Summary
Bethanechol chloride administration increased bladder pressure and decreased bladder capacity at which the desire to void is perceived. This study investigated bethanechol
Area of Science:
- Urology
- Pharmacology
- Physiology
Background:
- Bethanechol chloride is known to affect the urinary bladder.
- Its clinical efficacy in altering bladder function remains debated.
- Detrusor pressure increases have been documented, alongside potential sensory effects.
Purpose of the Study:
- To investigate the effects of subcutaneous bethanechol chloride on bladder pressure and capacity in neurologically intact men.
- To determine if bethanechol alters the perception of bladder fullness and the desire to void.
Main Methods:
- Cystometry was performed on 10 neurologically intact men.
- Measurements were taken before and 30 minutes after subcutaneous administration of 5 mg bethanechol chloride.
Main Results:
- Following bethanechol administration, the sensation of the desire to void occurred at a higher intravesical pressure.
- Maximum cystometric capacity was reached at a smaller bladder volume post-bethanechol.
- The perception of maximum bladder fullness was altered.
Conclusions:
- Subcutaneous bethanechol chloride influences bladder dynamics.
- It alters the intravesical pressure and bladder capacity associated with the perception of voiding desire and maximum fullness.