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Cytidine deaminase activity in abnormal pregnancy
T Okamura1, K Kigasawa, T Takeuchi
1Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Japan.
Summary
Cytidine deaminase (CTD) activity is elevated in abnormal pregnancies due to placental damage. This simple assay predicts fetal outcome in abnormal pregnancies, with higher CTD levels indicating a worse prognosis.
Area of Science:
- Biochemistry
- Obstetrics
- Perinatology
Background:
- Cytidine deaminase (CTD) is an enzyme involved in nucleotide metabolism.
- Placental function is critical for fetal development and pregnancy outcomes.
Purpose of the Study:
- To evaluate the utility of cytidine deaminase (CTD) activity for predicting abnormal pregnancy.
- To assess the prognostic value of CTD activity for fetal outcomes.
Main Methods:
- CTD activity was measured in 367 pregnant women, 17 placentas, and cord sera.
- Ammonia liberation during cytidine to uridine conversion quantified CTD activity.
- Statistical analysis included Kruskal-Wallis and paired t-tests.
Main Results:
- Placentas exhibited high CTD activity, unlike cord serum.
- Mean CTD activity was significantly higher in women with abnormal pregnancies compared to normal pregnancies.
- Two cases with CTD activity ≥40 U showed the poorest infant prognosis.
Conclusions:
- Elevated CTD activity in abnormal pregnancies correlates with placental damage and deterioration.
- The CTD assay is a straightforward method with predictive value for infant prognosis in abnormal pregnancies.