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[Expression of surface CD11b antigen and eosinophil activation]
1Department of Pediatrics, School of Medicine, Kanazawa University.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|March 1, 1993
Summary
Elevated CD11b on eosinophils indicates activation and reflects cytokine levels in allergic diseases like asthma. This adhesion molecule is key to eosinophil migration during inflammation.
Area of Science:
- Immunology
- Cell Biology
Context:
- Eosinophil migration is crucial in allergic inflammation.
- Adhesion molecules on eosinophils and endothelial cells mediate this process.
- The CD11b/ICAM-1 system is implicated in eosinophil-endothelial adhesion.
Purpose:
- To investigate the role of CD11b expression on eosinophils in allergic inflammation.
- To determine if CD11b expression correlates with eosinophil activation and cytokine levels.
Summary:
- CD11b expression on circulating eosinophils is significantly increased in allergic disorders such as atopic dermatitis and bronchial asthma.
- In vitro studies show that eosinophilopoietic cytokines (IL-3, IL-5, GM-CSF) rapidly upregulate surface CD11b expression on eosinophils.
- These findings suggest that CD11b is a marker of eosinophil activation.
Impact:
- Surface CD11b expression on eosinophils can serve as a valuable indicator of eosinophil activation.
- CD11b levels may reflect the in vivo concentration of eosinophilopoietic cytokines.
- Understanding CD11b's role can inform therapeutic strategies for allergic diseases.