Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human pituitary tumours: studies on genes expression

A C Cherñavsky1, A Chervin, M Vitale

  • 1Instituto de Neurociencias, Sanatorio Güemes, Buenos Aires, Argentina.

Neurological Research
|February 1, 1993
PubMed
Summary

Gene expression analysis of pituitary adenomas reveals higher c-myc oncogene mRNA in growth hormone-secreting tumors. This suggests a role for oncogenes in pituitary adenoma development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Maternal stress and fetoplacental cortisol regulation in small-for-gestational-age newborns.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2025
Same author

Evolution of echocardiographic and cardiac magnetic resonance imaging abnormalities during follow-up in patients with multisystem inflammatory syndrome in children.

European heart journal. Cardiovascular Imaging·2022
Same author

Fetal neurosonography at 31-35 weeks reveals altered cortical development in pre-eclampsia with and without small-for-gestational-age fetus.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2022
Same author

Self-rated health in individuals with and without disease is associated with multiple biomarkers representing multiple biological domains.

Scientific reports·2021
Same author

Degradation of estriol (E3) and transformation pathways after applying photochemical removal processes in natural surface water.

Water science and technology : a journal of the International Association on Water Pollution Research·2020
Same author

Transcranial Doppler as a useful tool in the detection of cervical steno-occlusive arteriopathy in infants.

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2019

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Oncology

Background:

  • Pituitary adenomas are common tumors, classified by hormone secretion.
  • Understanding the molecular basis of pituitary adenoma development is crucial.

Purpose of the Study:

  • To investigate differences in gene expression, specifically hormonal and oncogene mRNA, across pituitary adenoma subtypes.
  • To explore the potential role of oncogenes (c-myc, c-fos) in pituitary adenoma pathogenesis.

Main Methods:

  • Quantitative analysis of mRNA concentrations for prolactin, growth hormone, c-myc, and c-fos.
  • Study included 12 growth hormone-secreting, 7 prolactin-secreting, and 11 nonsecreting pituitary adenomas.

Main Results:

  • Hormonal gene expression correlated positively with clinical diagnoses.

Related Experiment Videos

  • c-myc and c-fos mRNA were detected in all adenoma types.
  • c-myc mRNA levels were significantly higher in somatotrophic (growth hormone-secreting) adenomas compared to prolactinomas and nonsecreting adenomas.
  • c-fos mRNA levels were similar across all adenoma types.

    • Conclusions:

    • Gene expression patterns, particularly oncogene levels, differ among pituitary adenoma subtypes.
    • Elevated c-myc expression in somatotrophic adenomas supports its potential role in tumor proliferation.
    • Oncogene products may contribute to pituitary adenoma formation through stimulation of DNA synthesis and cell proliferation.