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Umbilical cord blood stem cell transplantation
1Department of Pediatrics (Divisions of Hematology/Oncology and Bone Marrow Transplantation, University of Minnesota School of Medicine, Minneapolis.
The American Journal of Pediatric Hematology/Oncology
|May 1, 1993
Summary
Human umbilical cord blood stem cells (CBSCs) offer a promising alternative for hematopoietic stem cell transplantation. This review highlights their history and future potential in treating various diseases.
Area of Science:
- Hematology
- Stem Cell Biology
- Transplantation Medicine
Background:
- Human umbilical cord blood (HUCB) has emerged as a novel source for hematopoietic stem cells (HSCs).
- Initial research involved animal models and in vitro studies of human hematopoietic progenitors.
Purpose of the Study:
- To review the history of using cord blood stem cells (CBSCs) in transplantation.
- To explore the potential future applications of CBSCs.
Main Methods:
- Successful reconstitution of hematopoiesis using HUCB in a patient with Fanconi anemia in 1988.
- Subsequent use of HUCB for 15 pediatric patients with malignant and nonmalignant conditions.
Main Results:
- Demonstrated the efficacy of HUCB for hematopoietic reconstitution.
- Successfully treated diverse diseases including leukemia, lymphoma, neuroblastoma, Fanconi anemia, aplastic anemia, Hunter syndrome, and congenital immunodeficiency.
Conclusions:
- Cord blood stem cells (CBSCs) represent a significant advancement in transplantation medicine.
- HUCB transplantation has a proven track record and broad future potential for treating a range of hematologic and genetic disorders.