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Updated: Aug 4, 2026

New Tools to Expand Regulatory T Cells from HIV-1-infected Individuals
Published on: May 30, 2013
T-cell dysfunction in HIV infection: anergy due to defective antigen-presenting cell function?
L Meyaard1, H Schuitemaker, F Miedema
1Department of Clinical Viro-Immunology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam.
Abstract:
Before CD4+ T cells are depleted, T cells in asymptomatic HIV-infected individuals are functionally abnormal. These T cells are programmed for death, are non-responsive and fail to produce interleukin-2 after antigenic stimulation. Our view is that these different T-cell abnormalities are explained by the effects of HIV on antigen-presenting cells. Alteration of the functions of the antigen-presenting cell may program T cells for activation-induced death, and may induce anergy in interleukin-2 and interferon-gamma secreting TH1 cells. This results in predominance of TH2 allergic responses instead of cellular immunity dependent on TH1 cells.
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