Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunopathological changes in human cerebral malaria

J Porta1, A Carota, G P Pizzolato

  • 1Department of Pathology, CMU, University of Geneva, Switzerland.

Clinical Neuropathology
|May 1, 1993
PubMed
Summary

Cell-mediated immunity and tumor necrosis factor-alpha (TNF) play a role in severe malaria pathogenesis. Autopsy findings reveal leukocytes and TNF alongside infected cells, suggesting immune involvement in cerebral malaria.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Telemedicine in the management of patients with headache: current situation and recommendations of the Spanish Society of Neurology's Headache Study Group.

Neurologia·2023
Same author

Mass cytometry reveals cladribine-induced resets among innate lymphoid cells in multiple sclerosis.

Scientific reports·2022
Same author

SEDAR/SECCE ECMO management consensus document.

Revista espanola de anestesiologia y reanimacion·2021
Same author

Telemedicine in the management of patients with headache: current situation and recommendations of the Spanish Society of Neurology's Headache Study Group.

Neurologia·2021
Same author

In vitro propagation of Petasites hybridus (Asteraceae) from leaf and petiole explants and from inflorescence buds.

Plant cell reports·2019
Same author

Discoid meniscus in children and adolescents: Correlation between morphology and meniscal tears.

Revista espanola de cirugia ortopedica y traumatologia (English ed.)·2018

Area of Science:

  • Immunology
  • Pathology
  • Neuroscience

Background:

  • Pathogenic mechanisms of human cerebral malaria are not fully understood.
  • Severe malaria involves Plasmodium falciparum-infected erythrocytes sequestering in cerebral vessels.
  • Cell-mediated immunity and TNF are implicated in murine malaria models.

Observation:

  • Autopsy of a cerebral malaria patient revealed classic signs like erythrocyte sequestration, cerebral edema, and Dürck granulomas.
  • Leukocytes expressing CD68 and TNF coexisted with infected erythrocytes in capillaries.
  • Monocytes outnumbered erythrocytes in venules, and ICAM-1 was upregulated on endothelial cells with sequestered cells.

Findings:

  • The observed changes mirror those in murine models, suggesting a similar pathogenic role for cell-mediated immunity and TNF.

Related Experiment Videos

  • In vitro studies show ICAM-1 can bind to P. falciparum-infected erythrocytes.
  • High serum TNF levels correlate with malaria severity and may enhance cell adhesion via ICAM-1.

    • Implications:

    • These findings provide further evidence for the involvement of cell-mediated immunity in human cerebral malaria pathogenesis.
    • Understanding these mechanisms could lead to targeted therapies for severe malaria.
    • The study highlights the potential role of TNF and ICAM-1 in the adhesion of infected cells and leukocytes in cerebral malaria.