Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Preconditioning the human myocardium

D M Yellon1, A M Alkhulaifi, W B Pugsley

  • 1Department of Academic Cardiology, University College, London Medical School, UK.

Lancet (London, England)
|July 31, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An unusual "internal" penetrating liver injury.

BMJ case reports·2025
Same author

Inter-organ communication: pathways and targets to cardioprotection and neuro-protection. A report from the 12th Hatter Cardiovascular Institute workshop.

Basic research in cardiology·2024
Same author

The Infarct-Limiting Effect of Remote Ischemic Conditioning in Rats Is Not Affected by Aspirin.

Cardiovascular drugs and therapy·2023
Same author

Remote ischaemic conditioning: defining critical criteria for success-report from the 11th Hatter Cardiovascular Workshop.

Basic research in cardiology·2022
Same author

Correction: Hearts deficient in both Mfn1 and Mfn2 are protected against acute myocardial infarction.

Cell death & disease·2021
Same author

Targeting myocardial ischaemic injury in the absence of reperfusion.

Basic research in cardiology·2020
Same journal

Inherited retinal degenerations: clinical phenotypes and emerging therapies.

Lancet (London, England)·2026
Same journal

Documenting hospice care.

Lancet (London, England)·2026
Same journal

After the wood chipper.

Lancet (London, England)·2026
Same journal

Assisted dying and the silencing of medicine's next generation.

Lancet (London, England)·2026
Same journal

Linguistic pragmatism: a woman with progressive abdominal pain in Thailand.

Lancet (London, England)·2026
Same journal

Medical compartmentalisation: a patient with chromosome 22q11.2 deletion syndrome in Japan.

Lancet (London, England)·2026
See all related articles

Ischaemic preconditioning, involving short periods of ischemia with reperfusion, may protect the human heart. This study provides the first evidence that controlled intermittent ischemia can precondition and safeguard human heart muscle.

Area of Science:

  • Cardiology
  • Physiology

Background:

  • Ischaemic preconditioning (IP) is a potent endogenous cardioprotective mechanism observed in various animal species.
  • IP involves brief episodes of ischemia followed by reperfusion, rendering the myocardium resistant to subsequent prolonged ischemic injury.
  • Direct evidence for IP in the human heart remains limited.

Purpose of the Study:

  • To investigate the feasibility of inducing ischaemic preconditioning in the human myocardium.
  • To assess the protective effects of controlled intermittent ischemia and reperfusion in humans undergoing coronary artery bypass surgery.

Main Methods:

  • Study conducted during coronary artery bypass surgery.
  • Adenosine triphosphate (ATP) levels in myocardial biopsy specimens were measured as a key indicator of cellular energy status and protection.

Related Experiment Videos

  • Short, controlled periods of intermittent ischemia and reperfusion were applied.

    • Main Results:

    • The study demonstrated that the human myocardium could be subjected to preconditioning protocols.
    • Measurements indicated a potential protective effect, suggested by ATP levels, although specific data is not detailed in the abstract.
    • Results suggest the possibility of preconditioning the human heart.

    Conclusions:

    • This research presents the first evidence suggesting that ischaemic preconditioning may be achievable in the human heart.
    • Controlled intermittent ischemia and reperfusion show potential for protecting the human myocardium during cardiac surgery.
    • Further research is warranted to fully elucidate the mechanisms and clinical implications of human ischaemic preconditioning.