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Current dosage and schedule issues in the development of paclitaxel (Taxol)
S G Arbuck1, R Canetta, N Onetto
1Developmental Chemotherapy Section, National Cancer Institute, Bethesda, MD 20892.
Seminars in Oncology
|August 1, 1993
Abstract:
Basic questions regarding optimal dose and schedule of anticancer drug administration frequently persist long after regulatory approval and commercial availability of a drug. For paclitaxel (TAXOL), these questions were considered early in drug development. This paper reviews the available preclinical studies that assessed different drug concentrations and durations of drug exposure. The current status of clinical trials designed to help resolve these issues is also reviewed.